The article substantiates the determination of creativity as a culture-creating activity by the intellectual and personal activity of its subject. The contradictory self-realization of talent is expressed in the dynamics of his experiences and reflexive self-attitude, which are mediated by a system of sociocultural interactions as a space for personal development and professional growth of the subject in concrete historical conditions. These patterns are investigated in the scientific plan by means of a meaningful and semantic analysis of creativity based on the material of the life of the psychophysiologist-encyclopedist N. Ya. Perna. He developed an original method of reflexive psychological study of the psychobiography of the life path and productivity of the activities of outstanding talents. This was summarized by him in the fundamental concept of the rhythmology of life creation, an innovative contribution to the