The article presents the problem of psychological readiness for innovation activity in conditions of instability, uncertainty, complexity and ambiguity. The motivational, cognitive and personal components of psychological readiness for innovation are described. An approach to the description of the phenomenon of psychological readiness for innovation in the VUCA environment through the integrative resources of the individual as a subject of activity — innovative potential and self-regulation is presented. The structural components of innovation potential and personality-style characteristics of self-regulation in the VUCA environment are analyzed.